Project

Project 2 (3)
 
PRESENT PROJECTS
 
  1. Characterize IGF and insulin resistance by cytokines in adipocytes and myotubes
     
    1. Define effects on signals of IGF and insulin by TNF-ƒ¿ in adipocytes and myotubes
       
    2. Define effects on IGF and insulin-dependent glucose transport by TNF-ƒ¿ in adipocytes and myotubes
      • Define differential roles of IRS-1 and IRS-2 in insulin resistance by TNF-ƒ¿ in 3T3-L1 adipocytes
      • Define the compensating mechanisms in insulin resistance by TNF-ƒ¿ in L6 myotubes

     
  2. Characterize insulin resistance by GH in adipocytes and myotubes
     
    1. Define effects of GH on signals of insulin in adipocytes and myotubes
       
    2. Define effects of GH on insulin-dependent glucose transport in adipocytes and myotubes

     
  3. Elucidate molecular mechanisms of insulin resistance and its compensation in various model animals including GH-transgenic rats
 
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