- Elucidate mechanisms in potentiation of IGF-I signals by TSH in cell growth of thyroid follicular cells, FRTL-5 cells.
- Elucidate mechanisms by which cAMP-dependent priming effects potentiate IGF-I-dependent cell growth
- Define the roles of p125 tyrosine phosphorylation
- Define the roles of cAMP-dependent activation of src-family tyrosine kinase
- Define the roles of cAMP-dependent activation of PI 3-kinase cascade
- Elucidate mechanisms in cAMP-dependent potentiation of IGF-I signals
- Define the mechanisms in cAMP-dependent amplification of IGF-I-dependent tyrosine phosphorylation of Shc and its physiological role
- Define the mechanisms to potentiate IGF-I-dependent tyrosine phosphorylation of IRS-2, not IRS-1 and its physiological role
- Analyze interaction of cAMP and IGF-I in activation of MAP kinase cascade and PI 3-kinase cascade
- Define interacting effects of cAMP and IGF-I on cell cycle machinery including cyclins, cdk, cdk inhibitors, and Rb in FRTL-5 cells
- Elucidate the enhancement mechanisms of IGF-dependent cell differentiation of pre-adipocytes and myoblasts by other factors.
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