- Determine the stimuli to increases in insulin-sensitivity in liver
- Decreases in IGF-I secretion, ALS production or increases in IGFBP-1 production
- Decreases in insulin secretion
- GH or related hormones
- Nerve system
- Elucidation of the mechanisms to sensitize various tissues (liver, muscle) to insulin
- IRS amounts
- IRS intermolecular modification
- IRS localization
- Elucidation of the mechanisms to increase lipids in liver
- Effect on lipogenesis
- Effect on FFA uptake
- Effect on lipolysis
- Effect on FFA and TG release
- Determine effects on lipid metabolism in adipocytes and muscle
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