論文・総説など
現在の研究テーマに関係したもので、主に1996年6月以降

    【2023年度】
  1. Haruka Furuta, Yina Sheng, Ayaka Takahashi, Raku Nagano, Naoyuki Kataoka, Claire Marie Perks, Rachel Barker, Fumihiko Hakuno, Shin-Ichiro Takahashi. 2023 The IGF-Independent Role of IRS-2 in the Secretion of MMP-9 Enhances the Growth of Prostate Carcinoma Cell Line PC3. Int. J. Mol. Sci. doi: 10.3390/ijms242015065.
  2. Kondo Y, Aoki H, Masuda M, Nishi H, Noda Y, Hakuno F, Takahashi SI, Chiba T, Ishigami A. 2023 Moderate protein intake percentage in mice for maintaining metabolic health during approach to old age. Geroscience. doi: 10.1007/s11357-023-00797-3.
    3. 【2022年度】
  3. Matsuzaki T, Shimokawa Y, Koike H, Kimura M, Kawano Y, Okuma N, Kawamura R, Yoneyama Y, Furuichi Y, Hakuno F, Takahashi SI, Nakabayashi S, Okamoto S, Nakauchi H, Taniguchi H, Takebe T, Yoshikawa HY. 2022 Mechanical guidance of self-condensation patterns of differentiating progeny. iScience.25(10):105109. doi: 10.1016/j.isci.2022.105109.
  4. Yamanouchi K, Tanaka Y, Ikeda M, Kato S, Okino R, Nishi H, Hakuno F, Takahashi SI, Chambers J, Matsuwaki T, Uchida K. 2022 Macroglossia and less advanced dystrophic change in the tongue muscle of the Duchenne muscular dystrophy rat. Skelet Muscle. 12(1):24. doi: 10.1186/s13395-022-00307-7.
  5. Hongo H, Miyawaki S, Teranishi Y, Mitsui J, Katoh H, Komura D, Tsubota K, Matsukawa T, Watanabe M, Kurita M, Yoshimura J, Dofuku S, Ohara K, Ishigami D, Okano A, Kato M, Hakuno F, Takahashi A, Kunita A, Ishiura H, Shin M, Nakatomi H, Nagao T, Goto H, Takahashi SI, Ushiku T, Ishikawa S, Okazaki M, Morishita S, Tsuji S, Saito N. 2022 Somatic GJA4 gain-of-function mutation in orbital cavernous venous malformations.Angiogenesis. doi: 10.1007/s10456-022-09846-5.
  6. Zasu A, Hishima F, Thauvin M, Yoneyama Y, Kitani Y, Hakuno F, Volovitch M, Takahashi SI, Vriz S, Rampon C, Kamei H. 2022 NADPH-Oxidase Derived Hydrogen Peroxide and Irs2b Facilitate Re-oxygenation-Induced Catch-Up Growth in Zebrafish Embryo.Front Endocrinol (Lausanne). 13:929668. doi: 10.3389/fendo.2022.929668.
  7. Nishi H, Uchida K, Saito M, Yamanaka D, Nagata H, Tomoshige H, Miyata I, Ito K, Toyoshima Y, Takahashi S-I, Hakuno F and Takenaka A. 2022 Essential Amino Acid Intake Is Required for Sustaining Serum Insulin-like Growth Factor-I Levels but Is Not Necessarily Needed for Body Growth. Cells. 11(9):1523. doi: 10.3390/cells11091523
  8. 西宏起、高橋伸一郎 伯野史彦 2022 3. オルニチンが肝細胞の糖代謝遺伝子発現を制御する、バイオサイエンスとインダストリー　Vol.80 No.2
    9. 【2021年度】
  9. Goda Y, Yamanaka D, Nishi H, Masuda M, Kamei H, Kumano M, Ito K, Katsumata M, Yamanouchi K, Kataoka N, Hakuno F, Takahashi SI, 2021 Dietary lysine restriction induces lipid accumulation in skeletal muscle through an increase in serum threonine levels in rats. J. Biol. Chem. 297(4):101179 DOI: 10.1016/j.jbc.2021.101179
  10. Fukushima S, Nishi H, Kumano M, Yamanaka D, Kataoka N, Hakuno F, Takahashi SI, 2021 A novel amino acid signaling process governs glucose-6 phosphatase transcription. iScience. 24(7):102778. doi: 10.1016/j.isci.2021.102778. doi: 10.1016/j.isci.2021.102778.
  11. Miyamoto T, Uosaki H, Mizunoe Y, Han SI, Goto S, Yamanaka D, Masuda M, Yoneyama Y, Nakamura H, Hattori N, Takeuchi Y, Ohno H, Sekiya M, Matsuzaka T, Hakuno F, Takahashi SI, Yahagi N, Ito K, Shimano H. 2021 Rapid manipulation of mitochondrial morphology in a living cell with iCMM. Cell Rep. Methods. doi: 10.1016/j.crmeth.2021.100052.
  12. Nakura T, Ozoe A, Narita Y, Matsuo M, Hakuno F, Kataoka N, Takahashi SI, 2021 Rbfox2 mediates exon 11 inclusion in insulin receptor pre-mRNA splicing in hepatoma cells. Biochimie. 187: 25-32. doi: 10.1016/j.biochi.2021.05.007
  13. 伯野史彦、西宏起、山中大介、増田正人、高橋伸一郎 2021 3. 血中アミノ酸プロファイル変動を利用した新しい脂肪肝の改善法、実験医学　増刊 Vol.39 No.5 2021
  14. Zhang M, Lu P, Terada T, Sui M, Furuta H, Iida K, Katayama Y, Lu Y, Okamoto K, Suzuki M, Asakura T, Shimizu K, Hakuno F, Takahashi SI, Shimada N, Yang J, Ishikawa T, Tatsuzaki J, Nagata K 2021 Quercetin 3,5,7,3',4'-pentamethyl ether from Kaempferia parviflora directly and effectively activates human SIRT1, Commun. Biol. 4(1):209. doi: 10.1038/s42003-021-01705-1
    15. 【2020年度】
  15. Uchida K, Inoue K, Hasegawa Y, Hakuno F, Takahashi SI, Takenaka A 2020 Endogenous testosterone reduces hepatic lipid accumulation in protein-restricted male rats, Nutrition. 85:111130. doi: 10.1016/j.nut.2020.111130
  16. Nishi H, Yamanaka D, Masuda M, Goda Y, Ito K, Hakuno F, Takahashi S-I. 2020 Alteration of serum amino acid profiles by dietary adenine supplementation inhibits fatty liver development in rats, Sci. Rep. 10: 22110. doi: 10.1038/s41598-020-79234-w
  17. 鄭宏杰、中林靖、増田正人、西宏起、山中大介、高橋伸一郎、伯野史彦、宮内陽介、岡崎敬、吉田一寛、塩谷隆二、CNNに基づく鶏肝臓画像における脂肪肝分類に対する転移学習の効果検証、日本計算工学会論文集、2020巻、1号、p.20201003 https://doi.org/10.11421/jsces.2020.20201003
  18. 西宏起、合田祐貴、山中大介、勝俣昌也、中島一喜、潮秀樹、伯野史彦、高橋伸一郎　2020 栄養因子を利用した臓器特異的な脂肪蓄積調節法の開発　脂質・脂肪酸関連物質の使いこなし方―素材開発・機能創生・応用技術第9章
  19. 伯野史彦、沖野良輔、高橋伸一郎 2020 筋分化過程における細胞競合 -インスリン受容体基質（IRS-1）の役割　医学のあゆみ　Vol 274 No. 5 2020.8.1 (2020)
  20. Kenichi Ishibashi, Yoshihiro Takeda, Lisa Nakata, Fumihiko Hakuno, Shin-Ichiro Takahashi, Gen-ichi Atsumi. Elaidate, a trans fatty acid, suppresses insulin signaling for glucose uptake in a manner distinct from that of stearate, Biochimie. 177:98-107. Doi: 10.1016/j.biochi.2020.07.021. (2020)
  21. Otani L, Nishi H, Koyama A, Akasaka Y, Taguchi Y, Toyoshima Y, Yamanaka D, Hakuno F, Jia H, Takahashi SI, Kato H. Low-arginine and low-protein diets induce hepatic lipid accumulation through different mechanisms in growing rats. Nutr. Metab. (Lond). 17:60. Doi: 1186/s12986-020-00477-5.eCollection 2020. (2020)
  22. Toyoshima Y, Yoshizawa F, Tokita R, Taguchi Y, Takahashi SI, Kato H, Minami S., 2020 A translation repressor, 4E-BP1, regulates the triglyceride level in rat liver during protein deprivation., Am J Physiol Endocrinol Metab. 2020 May 1;318(5):E636-E645. doi: 10.1152/ajpendo.00464.2019. PMID: 32208000
  23. Okino R, Usui A, Yoneyama Y, Takahashi SI, Hakuno F., 2020 Myoblasts With Higher IRS-1 Levels Are Eliminated From the Normal Cell Layer During Differentiation., Front Endocrinol (Lausanne). 2020 Feb 28;11:96. doi: 10.3389/fendo.2020.00096. PMID: 32180762
  24. Hase K, Contu VR, Kabuta C, Sakai R, Takahashi M, Kataoka N, Hakuno F, Takahashi SI, Fujiwara Y, Wada K, Kabuta T., 2019 Cytosolic domain of SIDT2 carries an arginine-rich motif that binds to RNA/DNA and is important for the direct transport of nucleic acids into lysosomes., Autophagy. 2020 Jan 16:1-15. doi: 10.1080/15548627.2020.1712109. [Epub ahead of print], PMID: 31944164
    25. 【2019年度】
  25. Takahashi SI., 2019 IGF research 2016-2018., Growth Horm IGF Res. 2019 Oct - Dec;48-49:65-69. doi: 10.1016/j.ghir.2019.10.004. Epub 2019 Nov 6. Review., PMID: 31706074
  26. Yagi T, Toyoshima Y, Tokita R, Taguchi Y, Okamoto Y, Takahashi SI, Kato H, Minami S., 2019 Low-protein diet enhances adiponectin secretion in rats., Biosci Biotechnol Biochem. 2019 Sep;83(9):1774-1781. doi: 10.1080/09168451.2019.1621153. Epub 2019 May 27., PMID: 31130066
  27. Masaki S, Ikeda S, Hata A, Shiozawa Y, Kon A, Ogawa S, Suzuki K, Hakuno F, Takahashi SI, Kataoka N., 2019 Myelodysplastic Syndrome-Associated SRSF2 Mutations Cause Splicing Changes by Altering Binding Motif Sequences., Front Genet. 2019 Apr 16;10:338. doi: 10.3389/fgene.2019.00338. eCollection 2019., PMID: 31040863
  28. Ueda K, Nakatsu Y, Yamamotoya T, Ono H, Inoue Y, Inoue MK, Mizuno Y, Matsunaga Y, Kushiyama A, Sakoda H, Fujishiro M, Takahashi SI, Matsubara A, Asano T., 2019 Prolyl isomerase Pin1 binds to and stabilizes acetyl CoA carboxylase 1 protein, thereby supporting cancer cell proliferation., Oncotarget. 2019 Feb 26;10(17):1637-1648. doi: 10.18632/oncotarget.26691. eCollection 2019 Feb 26., PMID: 30899433
  29. Nakatsu Y, Matsunaga Y, Yamamotoya T, Ueda K, Inoue MK, Mizuno Y, Nakanishi M, Sano T, Yamawaki Y, Kushiyama A, Sakoda H, Fujishiro M, Ryo A, Ono H, Minamino T, Takahashi SI, Ohno H, Yoneda M, Takahashi K, Ishihara H, Katagiri H, Nishimura F, Kanematsu T, Yamada T, Asano T., 2019 Prolyl Isomerase Pin1 Suppresses Thermogenic Programs in Adipocytes by Promoting Degradation of Transcriptional Co-activator PRDM16., Cell Rep. 2019 Mar 19;26(12):3221-3230.e3. doi: 10.1016/j.celrep.2019.02.066., PMID: 30893596
  30. Masaki S, Ikeda S, Hata A, Shiozaki Y, Kon A, Ogawa S, Suzuki K, Hakuno F, Takahashi SI, Kataoka N. 2019 Myelodysplastic Syndrome-Associated SRSF2 Mutations Cause Splicing Changes By Altering Binding Motif Sequences. Front. Genet., 16 April 2019 doi.org/10.3389/fgene.2019.00338
  31. 高橋伸一郎、伯野史彦、山中大介、中林　靖、豊島由香、竹中麻子 2019 3. インスリン様シグナルと代謝制御性アミノ酸シグナル　-次世代栄養学「AI Nutrition」の提唱-、実験医学 Vol.37 No.4 （3月号）
    32. 【2018年度】
  32. 高橋伸一郎、伯野史彦 2018 12. 成長ホルモンは、実は「異化ホルモン」である 成長 代謝 Vol.9 No.2, 2018
  33. 西宏起、伯野史彦、高橋伸一郎 2018 11. アミノ酸の新機能「血中プロファイルに応じた脂質代謝の変動」　バイオサイエンスとインダストリー　別冊
  34. Furuta H, Yoshihara H, Fukushima T, Yoneyama Y, Ito A, Worrall C, Girnita A, Girnita L, Yoshida M, Asano T, Komada M, Kataoka N, Chia K, Hakuno F, Takahashi SI. 2018 IRS-2 deubiquitination by USP9X maintains anchorage-independent cell growth via Erk1/2 activation in prostate carcinoma cell line. Oncotarget 9:33871-33883 Doi: https://doi.org/10.18632/oncotarget.26049
  35. Yoneyama Y, Inamitsu T, Chida K, Iemura S, Natsume T, Maeda T, Hakuno F, Takahashi SI. 2018 Serine phosphorylation by mTORC1 promotes IRS-1 degradation through SCFb-TRCP E3 ubiquitin ligase. iScience Doi: 10.1016/j.isci.2018.06.006
  36. Yoneyama Y, Lanzerstorfer P, Niwa H, Umehara T, Shibano T, Yokoyama S, Chida K, Weghuber J, Hakuno F, Takahashi SI. 2018 IRS-1 acts as an endocytic regulator of IGF-I receptor to facilitate sustained IGF signaling. eLife. pil: e32893. Doi: 10.7554/eLife.32893.
  37. Nishi H, Yamanaka D, Kamei H, Goda Y, Kumano M, Toyoshima Y, Takenaka A, Masuda M, Nakabayashi Y, Shioy R, Kataoka N, Hakuno F, Takahashi S-I. 2018 Importance of serum amino acid profile for induction of hepatic steatosis under protein malnutrition, Sci. Rep. 8: 5461. doi: 10.1038/s41598-018-23640-8
  38. Hakuno F, Takahashi S-I. 2018 IGF-I receptor signaling. J Mol Endocrinology. pil: JME-17-0311. doi: 10.1530/JME-17-0311
  39. Kamei H, Yoneyama Y, Hakuno F, Sawada R, Shimizu T, Duan C, Takahashi SI. 2018 Catch-Up Growth in Zebrafish Embryo Requires Neural Crest Cells Sustained by Irs1 Signaling. Endocrinology. 159(4): 1547-1560. Doi: 10.1210/en.2017-00847
    40. 【2017年度】
  40. Horiuchi M, Takeda T, Takanashi H, Ozaki-Masuzawa Y, Taguchi Y, Toyoshima Y, Otani L, Kato H, Sone-Yonezawa M, Hakuno F, Takahashi SI, Takenaka A. 2017 Branched-chain amino acid supplementation restores reduced insulinotropic activity of a low-protein diet through the vagus nerve in rats. Nutr Metab (Lond). 14:59. doi: 10.1186/s12986-017-0215-1. eCollection 2017.
  41. Contu VR, Hase K, Kozuka-Hata H, Oyama M, Fujiwara Y, Kabuta C, Takahashi M, Hakuno F, Takahashi SI, Wada K, Kabuta T. Lysosomal targeting of SIDT2 via multiple YxxΦ motifs is required for SIDT2 function in the process of RNautophagy.J Cell Sci. 2017 Sep 1;130(17):2843-2853. doi: 10.1242/jcs.202481. Epub 2017 Jul 19.
  42. Taguchi Y, Tokita R, Kato H, Takahashi S-I, Miami S, Toyoshima Y. 2017 Triglyceride synthesis in hepatocytes isolated from rats fed a low-protein diet is enhanced independently of upregulation of insulin signaling Biochem. Biophys. Res. Comun. In press.
  43. 高橋伸一郎、竹中麻子 2017 4. 生命科学のここがおもしろい：生命科学って何だろう 岩波ジュニア新書「今、農学がおもしろい」（岩波書店）
  44. 高橋伸一郎 2017 進化学者に聞く！学生からの10の質問 日本進化学ニュース 18(2) 2-5.
  45. 高橋伸一郎 2017 私たちの身近にあるタンパク質を科学する 「科学の技法」（増田、坂口編） 東京大学出版会 pp. 76-79
  46. 高橋伸一郎 2017 栄養失調の研究から高品質食資源の開発法を見いだす 弥生 64: 2-3.
  47. 高橋伸一郎 2017 「まあ、いいか」の子育てのすすめ. 赤ちゃん歯科ネットワーク.
  48. Yokokura T, Kamei H, Shibano T, Yamanaka D, Sawada-Yamaguchi R, Hakuno F, Takahashi S-I, Shiimizu T. 2017 The short-stature homeobox-containing gene (shox/SHOX) is required for the regulation of cell Proliferation and Bone Differentiation in Zebrafish embryo and human Mesenchymal stem cells. Frontier in Endocrinology Volume 8, Article 125. doi: 10.1507/endocrj.EJ16-0319.
  49. Fukushima T, Yoshihara H, Furuta H, Hakuno F, Iemura S-I, Natsume T, Nakatsu Y, Kamata H, Asano T, Komada M, Takahashi S-I. 2017 USP15 attenuates IGF-I signaling by antagonizing Nedd4-induced IRS-2 ubiquitination. Biochem. Biophys. Res. Comun. 484: 522-528. doi: 10.1016/j.bbrc.2017.01.101
  50. Ariga M, Yoneyama Y, Fukushima T, Ishiuchi Y, Ishii T, Sato H, Hakuno F, Nedachi T, Takahashi SI. 2017 Glucose deprivation attenuates sortilin levels in skeletal muscle cells. Endocr J. 64(3):255-268. doi: 10.1507/endocrj.EJ16-0319.
  51. Takagi H, Nishibori Y, Katayama K, Katada T, Takahashi S, Kiuchi Z, Takahashi SI, Kamei H, Kawakami H, Akimoto Y, Kudo A, Asanuma K, Takematsu H, Yan K. USP40 gene knockdown disrupts glomerular permeability in zebrafish. Am J Physiol Renal Physiol. 2017 Apr 1;312(4): F702-F715. doi: 10.1152/ajprenal.00197.2016.
  52. Worrall C, Suleymanova N, Crudden C, Trocoli I, Candrea E, Nedelcu D, Takahashi S-I, Girnita L, Girnita A. 2017 Unbalancing p53/Mdm2/IGF-1R axis by Mdm2 activation restrains the metastatic phenotype of skin melanoma. Oncogene. 1-13
    53. 【2016年度】
  53. 高橋伸一郎、福嶋俊明、山中大輔、伯野文彦 2016 だれでもわかる甲状腺の基礎知識「甲状腺の細胞増殖誘導機構」 日本甲状腺学会誌 7(1): 75
  54. 松岡享子、荒井督子、高橋伸一郎、吉田敦子、中田かず子、石田房枝 2016　座談会　東京子ども図書館　松岡享子先生を囲んで　赤ちゃんのこころとからだを育てる 赤ちゃん歯科ネットワーク 2: 2-16
  55. Masuda M, Nakabayashi Y, Shioya R, Nishi H, Takahashi S-I. Hakuno F. 2016 Study of effects of blood amino acid and hormone leel for controlling triglyceride accumulation in the liver of rats using Self-Organizing Map. International Journal of Intelligent Information Systems 5 (6): 88-93. http://www.sciencepublishinggroup.com/j/ijiis doi: 10.11648/j.ijiis.20160506.12. ISSN: 2328-7675 (Print); ISSN: 2328-7683 (Online)
  56. Liu TY, Yu BC, Kakino M, Fujimoto H, Ando Y, Hakuno F, Takahashi S-I. 2016 A novel IRS-1-associated protein, DGKζ regulates GLUT4 translocation in 3T3-L1 adipocytes. Scientific Reports. 6:35438, DOI: 10.1038/srep35438
  57. Takeuchi S, Nakano S, Nakamura K, Ozoe A, Chien P, Yoshihara H, Hakuno F, Matsuwaki T, Saeki Y, Takahashi S-I, Ymanouchi K, Nishihara M. 2016 Roles瀰f瀋hondroitin sulfate proteoglycan 4瀛n fibrogenic/adipogenic differentiation in skeletal muscle tissues. Exp Cell Res.47(2):367-77. doi: 10.1016/a°j.yexcr.2016.08.023. Epub 2016 Aug 28.
  58. Yamanaka D, Akama T, Chida K, Minami S, Ito K, Hakuno F, Takahashi S-I. 2016 Phosphatidylinositol 3-Kinase-Associated Protein (PI3KAP)/XB130 Crosslinks Actin Filaments through Its Actin Binding and Multimerization Properties In Vitro and Enhances Endocytosis in HEK293 Cells. Front Endocrinol (Lausanne).:89. doi: 10.3389/fendo.2016.00089. eCollection 2016.
  59. Otani L, Mori T, Koyama A, Takahashi S-I, Kato H. 2016 Supplemental arginine above the requirement during suckling causes obesity and insulin resistance in rats. Nutrition Research 36: 575-585 DOI information: 10.1016/j.nutres.2016.01.007