論文・総説など
現在の研究テーマに関係したもので、主に1996年以降

  1. 高橋伸一郎 2015 書評：せいめいのれきし　こどもとしょかん 秋 2015: 22
  2. 高橋伸一郎、潮秀樹、加藤久典、伯野史彦、柴田重信、竹中麻子、豊島由香、勝俣昌也、中島一喜 2016 アミノ酸シグナルを利用した高品質食資源の開発技術の確立. JATAFFジャーナル4-4　トピックス
  3. Girnita L, Takahashi S-I, Crudden C, Fukushima T, Worrall C, Furuta H, Yoshihara H, Hakuno F, Girnita A. 2016 When phosphorylation encounters ubiquitination: A balanced perspective on IGF-1R signaling Progress in Molecular Biology and Translational Science, pp. 1-35. ISSN 1877-1173, http://dx.doi.org/10.1016/bs.pmbts.2016.04.001 , 2016 Elsevier Inc.
  4. 高橋伸一郎、福嶋俊明、安藤康年、伯野史彦 2016 インスリン受容体基質を含む巨大分子複合体を介した新しいインスリン様活性調節機構　バイオサイエンスとインダストリー 74: 21-25.
  5. Ozaki Y, Saito K, Nakazawa K, Konishi M, Itoh N, Hakuno F, Takahashi S-I, Kato H, Takenaka A. Rapid increases of fibroblast growth factor 21 under protein malnutrition and its impact on growth and lipid metabolism. Brit. J. Nutr. In press
  6. Hase K, Fujiwara Y, Kikuchi H, Aizawa S, Hakuno F, Takahashi S-I, Wada K, Kabuta T. 2015 RNautophagy/ DNautophagy possesses selectivity for RNA/DNA substrates. Nucleic Acids Res. Pii: gkv579. doi: 10.1093/nar/gkv579
  7. Matsunaga Y, Bajatsu Y, Fukushima T, Okubo H, Iwashita M, Sakoda H, Fujishiro M, Yamamotoya T, Kushiyama A, Takahashi S-I, Tsuchiya Y, Kamata H, Togunaga F, Iwai K, Asano T. LUBAC formation is impaired in the livers of mice with MCD-dependent non-alcoholic steatohepatitis. Mediators of inflammation. In press
  8. Shibano T, Mamada H, Hakuno F, Takahashi S-I, Taira M. 2015 The inner nubclear membrane protein Nemp1 is a ney typ of RanGTP-binding protein in eukaryotes. PLOS ONE, May 6, 2015 1. DOI: 10.1371/journal.pone.0127271
  9. Hakuno F, Fukushima T, Yoneyama Y, Kame H, Ozoe A, Yoshihara H, Yamanaka D, Shibano T, Sone-Yonezawa M, Yu B-C, Chida K, Takahashi S-I. 2015 The novel functions of high-molecular-mass complexes containing insulin receptor substrates in mediation and modulation of insulin-like activities: Emerging concept of diverse function by IRS-associated proteins. Frontiers in Endocrinology. Volume 6 Article 73. doi: 10.3389/fendo.2015.00073
  10. Fukushima T, Yoshihara H, Furuta H, Kamei H, Hakuno F, Luan J, Duan C, Saeki Y, Tanaka K, Iemura S, Natsume T, Chida K, Nakatsu Y, Kamata H, Asano T, Takahashi S. 2015. Nedd4-induced monoubiquitination of IRS-2 enhances IGF signaling and mitogenic activity. Nat Commun. 16;6:6780. doi: 10.1038/ncomms7780
  11. Lanzerstofer P, Yoneyama Y, Hakuno F, Muller U, Hoglinger O, Takahashi S, Weghuber J. 2015. Analysis of insulin receptor substrate signaling dynamics on microstructured surfaces. FEBS J. 282 (6): 987-1005. doi: 10.1111/febs.13213.
  12. Ando Y, Shinozawa Y, Iijima Y, Yu BC, Sone M, Ooi Y, Watanaka Y, Chida K, Hakuno F, Takahashi S. 2015. Tumor necrosis factor (TNF)-alpha-induced repression of GKAP42 protein levels through cGMP-dependent kinase (cGK)-Ialpha causes insulin resistance in 3T3-L1 adipocytes. J Biol Chem. 290 (9): 5881-92 doi: 10.1074/jbc.M114.624759.
  13. Sawada R, Kamei H, Hakuno F, Takahashi S, Shimizu T. 2015. In vivo loss of function study reveals the short stature homeobox-containing (shox) gene plays indispensable roles in early embryonic growth and bone formation in zebrafish. Dev Dyn. 244 (2): 146-56. doi: 10.1002/dvdy.24239.
  14. Wang L, Kaneko G, Takahashi S-I, Watabe S, Ushio H. 2014 Identification and gene expression profile analysis of a major type of ipoprotein lipase in adult medak Oryzias latipes. Fish Sci. published on line 30 November 2014. DOI 10.1007/s12562-014-0826-7
  15. Yokota S-I, Nakamura K, Ando M, Kamei H, Hakuno F, Takahashi S-I, Shibata S. 2014 Acetylcholinesterase (AChE) inhibition aggravates fasting-induced triglyceride accumulation in the mouse liver. FEBS Open Bio. 4, 905-914. http://dx.doi.org/10.1016/j.fob.2014.10.009
  16. Toyoshima Y, Tokita R, Taguchi Y, Akiyama-Akanishi N, Takenaka A, Kato H, Chida K, Hakuno F, Minami S, Takahashi S-I. 2014 Tissue-specific effects of protein malnutrition on insulin signaling pathway and lipid accumulation in growting rats. Endocrine J. 61: 499-512.
  17. Ozaki Y, Takeda T, Akiyama-Akanishi N, Hakuno F, Toyoshima Y, Takahashi S-I, Takenaka A. 2014 Insulin injection restores increased insulin receptor substrate (IRS)-2 protein during short-term protein restriction but does not affect reduced insulin-like growth factor (IGF)-I mRNA or increased triglyceride accumulation in the liver of rats. Biosci. Biotech. Biochem. 78(1):130-8. doi: 10.1080/09168451.2014.877825.
  18. Girnita L, Worrall C, Takahashi S-I, Seregard S, Girnita A. 2014 Something old, something new and something borrowed; emerging paradigm of insulin-like growth factor type 1 receptor (IGF-1R) signaling regulation. Cellular and Molecular Life Sciences. 71(13):2403-27.
  19. Ozoe A, Sone M, Fukushima T, Kataoka N, Chida K, Asano T, Hakuno F, Takahashi S-I. 2014 Insulin receptor substrate-1 associates with small nucleolar RNA which contributes to ribosome biogenesis. Frontiers in Endocrinology 5: Article 24, 1-12.
  20. Toyoshima Y, Tokita R, Taguchi Y, Akiyama-Akanishi N, Takenaka A, Kato H, Chida K, Hakuno F, Minami S, Takahashi S-I. 2014 Tissue-specific effects of protein malnutrition on insulin signaling pathway and lipid accumulation in growting rats. Endocrine J. in press.
  21. Ozaki Y, Takeda T, Akiyama-Akanishi N, Hakuno F, Toyoshima Y, Takahashi S-I, Takenaka A. 2014 Insulin injection restores increased insulin receptor substrate (IRS)-2 protein during short-term protein restriction but does not affect reduced insulin-like growth factor (IGF)-I mRNA or increased triglyceride accumulation in the liver of rats. Biosci. Biotech. Biochem. In press
  22. 高橋伸一郎、金子元、竹中麻子、東祐輔、尾添淳文、伯野史彦 2013 酸化ストレスとインスリン様活性の相互作用が健康寿命延伸に果たす役割 医学のあゆみ 247: 第五土曜特集「活性酸素：基礎から病態解明・制御まで」
  23. 山中大介、高橋伸一郎、伯野史彦、南史郎　2013 新規アダプタータンパク質XB130はがん細胞において腫瘍発達を抑制するマイクロRNAの発現を制御する　日本甲状腺学会誌　4 (2): 139
  24. 高橋伸一郎、伯野史彦、亀井宏泰、Leonard Girnita、Ignacio Torres-Aleman、東祐輔、福嶋俊明、柴野卓志、尾添淳文、山中大介　解説：インスリン様活性と高齢化社会で克服すべき疾病　2013 化学と生物　51: 389-399
  25. 高橋伸一郎 2013「農学入門」第三部10章「農学と動物科学：巨大な細胞社会を統御する仕組みを知り利用する」養賢堂
  26. Kawashima Y, Hakuno F, Okada S, Hotsubo T, Kinoshita T, Fujimoto M, Nishimura R, Fukushima T, Hanak K, Takahashi S-I, Kanzaki S. 2013 Familial short stature is associated with a novel dominant-negative heterozygous insulin-like growth factor 1 receptor (IGF1R) mutation. Clin. Endocrinol. In press
  27. Ozoe A, Sone M, Fukushima T, Kataoka N, Arai T, Chida K, Asano T, Hakuno F, Takahashi S-I. 2013 Insulin Receptor Substrate-1 (IRS-1) Forms a Ribonucleoprotein Complex Associated with Polysomes. FEBS Lett. 587(15):2319-24.
  28. Yoneyama Y, Matsuo M, Take K, Kabuta T, Chida K, Hakuno F, Takahashi S-I. 2013 AP-1 complex regulates endosomal localization of insulin receptor substrate -1 required for insulin-like growth factor-I-dependent DNA synthesis. Mol. Cell Biol. 33(10):1991-2003.
  29. Ozaki Y, Kaneko G, Hakuno F, Takahashi S-I, Watabe S. Detection of insulin-like growth factor-like activity in the aqueous extracts of the rotifer Brachionus plicatilis. Fisheries Science. DOI 10.1007/s12562-01200570-9.
  30. Otani Y, Nakatsu Y, Sakoda H, Fukushima T, Fujishiro M, Kushiyama A, Okubo H, Tsuchiya Y, Ohno H, Takahashi S, Nishimura F, Kamata H, Katagiri H, Asano T. 2013 Integrator complex plays anessential role inadipose differentiation. Biochem Biophys Res Commun. 434(2):197-202.
  31. Fukushima T, Nakamura Y, Yamanaka D, Shibano T, Chida K, Minami S, Asano T, Hakuno F, Takahashi S-I. 2012 Phosphatidylinsitol 3-kinase (PI3K) activity bound to insulin-like growth factor-I (IGF-I) receptor, which is continuously sustained by IGF-I stimulation, is required for IGF-I-induced cell proliferation. J. Biol. Chem. 287: 29713-29721.
  32. Yoshihara H, Fukushima T, Hakuno F, Saeki Y, Tanaka K, Ito A, Yoshida M, Iemura SI, Natsume T, Asano T, Chida K, Girnita L, Takahashi SI. 2012 Insulin/insulin-like growth factor (IGF) stimulation abrogates an association between a deubiquitinating enzyme USP7 and insulin receptor substrates (IRSs) followed by proteasomal degradation of IRSs. Biochem Biophys Res Commun. 423: 122-127.
  33. Yamanaka D, Akama T, Fukushima T, Nedachi T, Kawasaki C, Chida K, Minami S, Suzuki K, Hakuno F, Takahashi S-I. 2012 Phosphatidylinositol 3-kinase binding protein, PITKAP/XB130 is required for cAMP-induced amplification of IGF mitogenic activity in FRTL-5 thyroid cells. Mol Endocrinol. 26: 1043-1055.
  34. Nakae J, Cao Y, Hakuno F, Takemori H, Kawano Y, Sekioka R, Abe T, Kiyonari H, Tanaka T, Sakai J, Takahashi S-I, Itoh H. 2012 A novel repressor regulates insulin sensitivity through interaction with Foxo1. EMBO J 31: 2275-2295.
  35. Sue M, Kawashima A, Hayashi M, Akama T, Tanigawa K, Yoshihara A, Hara T, Ishido Y, Ito T, Takahashi S-I, Ishii N, Suzuki K. 2012 Thyroglobulin (Tg) activates MAPK/ERK pathways to induce thyroid cell growth in the absence of TSH, insulin and serum. Biochem. Biophys. Res. Commun. 420: 611-615.
  36. Nishizawa H, Handayaningsih A-E, Iguchi G, Cho Y, Takahashi M, Yamamoto M, Suda K, Kasahara K, Hakuno F, Yamanouchi K, Nishihara M, Seino S, Takahashi S-I, Takahashi Y. 2012 Enhanced oxidative stress in GH-transgenic rat and acromegaly. GH-IGF Research 22: 64-68.
  37. Kawashima Y, Higaki K, Fukushima T, Hakuno F, Nagishi J-I, Hanaki K, Nanba E, Takahashi S-I, Kanzaki S. 2012 DNovel missense mutation in the IGF-I receptor L2 domain results in intrauterine and postnatal growth retardation. Clin. Endocrinol(Oxf) 77: 246-254.
  38. Yuki Kawashima, Shin-Ichiro Takahashi, Susumu Kanzaki.2012 Familial short stature with IGF-I receptor gene anomaly. Endocrine J. 59: 179-85
  39. Sureshbabu A, Okajima H, Yamanaka D, Tonner E, Shastri S, Maycock J, Szymanowska M, Shand J, Takahashi S-I, Beattie J, Allan GJ, and Flint DJ. 2012 IGFBP-5 induces cell adhesion, increases cell survival and inhibits cell migration in MCF-7 human breast cancer cells. J Cell Sci. 125: 1693-705
  40. 高橋伸一郎 2011 Column: IGFの話をしよう！第１回 インスリン様成長因子の性質 ソマバート症例報告集 vol.1 pp.8-11、第2回 インスリン様成長因子結合タンパク質の性質　ソマバート症例報告集 vol. 2 pp.8-11、第3回 インスリン様成長因子が作用を発現する仕組み　ソマバート症例報告集 vol. 3 pp.8-11、第4回 インスリン様成長因子の活性を制御する仕組みとその意義　
  41. 高橋伸一郎 2011 IGF活性を修飾する機構の多様性　Forum on GH Research 2010 pp.11-13
  42. Hakuno F, Yamauchi Y, Kaneko G, Yoneyama Y, Nakae J, Chida K, Kadowaki T, Yamanouchi K, Nishihara M, Takahashi S-I. 2011 Constitutive Expression of Insulin Receptor Substrate (IRS)-1 Inhibits Myogenic Differentiation through Nuclei Exclusion of Foxo1 in L6 Myoblasts. PLoS ONE 6(10): e25655. doi:10.1371/journal.pone.0025655
  43. Fukushima T, Okajima H, Yamanaka D, Ariga-Nedachi M, Nagata S, Ito A, Yoshida M, Asano T, Minami S, Chida K, Hakuno F, Takahashi S-I. 2011 HSP90 interacting with IRS-2 is involved in cAMP-dependent potentiation of IGF-I signals in FRTL-5 cells. Mol Cell Endocrinol 344: 81-89.
  44. Hara T, Miyazaki, Hakuno F, Takahashi S-I, Chida K. 2011 PKChpromotes a proliferation to differentiation switch in keratinocytes via up-regulation of p27Kip1 mRNA through suppression of JNK/c-Jun signaling under stress conditions. Cell Death Dis 2:e157.
  45. Yoshihama Y, Sasaki K, Horikoshi Y, Suzuki A, Ohtsuka T, Hakuno F, Takahashi S-I, Ohno S, Chida K 2011 KIBRA suppresses apical exocytosis through inhibition of aPKC kinase activity in epithelial cell. Current Biology 21: 705-711
  46. Nakatsu Y, Sakoda H, Kushiyama A, Ono H, Fujishiro M, Horike N, Kikuchi T, Yoneda M, Ohno H, Kanna M, Kamata H, Nishimura F, Isobe T, Ogihara T, Kadowaki T, Katagiri H, Oka Y, Takahashi S-I, Kurihara H, Uchida T, Asano T. 2011 Role of peptidyl-prolyl cis/trans isomerase NIMA-interacting 1 in insulin signaling and diet-induced obesity. J Biol Chem 286: 20812-20822
  47. Fukushima T, Arai T, Ariga M, Okajima H, Ooi Y, Iijima Y, Sone M, Cho Y, Ando Y, Kasahara K, Ozoe A, Yoshihara H, Chida K, Okada S, Kopchick JJ, Hakuno F, Takahashi S-I. 2011 Insulin receptor substrates form high-molecular-mass complexes that modulate their availability to insulin/insulin-like growth factor-I receptor tyrosine kinases. Biochem Biophys Res Commun 404: 767-773
  48. Toyoshima Y, Tokita R, Ohne Y, Hakuno F, Noguchi T, Minami S, Kato H, Takahashi S. 2010 Dietary protein deprivation upregulates insulin signaling and inhibits gluconeogenesis in rat liver. J Mol Endocrinol. 45: 329-40
  49. Nakatsu Y, Sakoda H, Kushiyama A, Ono H, Fujishiro M, Horike N, Yoneda M, Ohno H, Kamata H, Nishimura F, Ogihara T, Katagiri H, Oka Y, Fukushima T, Takahashi S-I, Kurihara H, Uchida T, Asano T. 2010 Pin1 associates with and induces translocation of CRTC family proteins to the cytosol, thereby suppressing CRE transcriptional activity. J Biol Chem 43: 33018-33027.
  50. Takahashi S-I Physiological significance of potentiation of IGF bioactivity by other factors: mechanisms underlying modulation of IGF signaling. Journal of Physiological Sciences. In press
  51. Shibata M, Hakuno F, Okajima H, Yamanaka D, Okajima H, Fukushima T, Hasegawa T, Ogata T, Toyoshima Y, Chida K, Kimura K, Sakoda H, Takenaka A, Asano T, Takahashi S-I. 2010 Paraquat-induced oxidative stress represses PI 3-kinase activities leading to impaired glucose uptake in 3T3-L1 adipocytes. J Biol Chem. 285: 20915-25
  52. Kabuta T, Hakuno F, Cho Y, Yamanaka D, Chida K, Asano T, Wada K, Takahashi S-I. 2010 Insulin receptor substrate-3, interacting with Bcl-3, enhances p50 NF-kB activity. Biochem. Biophys. Res. Commun. 394: 697-702.
  53. Kimura K., Katsumata Y., Ozawa T., Tawara S., Igarashi K., Cho Y., Shibata M., Hakuno F., Takahashi S.-I., and Takenaka A. 2010 Effect of paraquat-induced oxidative stress on insulin regulation of insulin-like growth factor-binding protein-1 gene expression. J. Clin. Biochem. Nutr., 46: 157-167.
  54. 高橋伸一郎、竹中麻子、豊島由香、木村久美、加藤久典、福嶋俊明、山中大介、伯野史彦、南史朗、岩下光利　2010 発達と成長を司るホルモン、インスリン様成長因子　日本未熟児新生児学会雑誌 22: 19-25.
  55. 高橋伸一郎、福嶋俊明、岡嶋裕志、伯野史彦、豊島由香、竹中麻子 2009成長ホルモン、インスリン様成長因子、インスリンの代謝活性の連携　ホルモンと臨床　57: 307-317.
  56. Sureshbabu A, Okajima H, Yamanake Y, Shastri S, Tonner E, Rae C, Szymanowska M, Shand JH, Takahashi S-I, Beattie J, Allan GJ, Flint DJ 2009 IGFBP-5 induces epithelial and fibroblast responses consistent with the fibrotic response. Biochemical Society Transactions 37: 882−885
  57. Morita J, Hakuno F, Hizuka N, Takahashi S-I, Takanao K. 2009 Growth hormone (GH) and insulin-like growth factor (IGF)-I represses 11b-hydroxysteroid dehydrogenase type 1 (HSD1) mRNA expression in 3T3-L1 cells and its activity in their homogenates. Endocrine J. 56: 561-70
  58. 岡嶋裕志、伯野史彦　高橋伸一郎 2009インスリン様成長因子（IGF）「炎症・再生医学辞典」 pp. 532-534. 朝倉書店
  59. Sasaki-Suzuki N, Arai K, Ogata T, Kasahara K, Sakoda H, Chida K, Asano T, Pessin JE, Hakuno F, Takahashi S-I. 2009　GH inhibition of glucose uptake in adipocytes occurs without affecting GLUT4-translocation through an IRS-2-PI 3-kinase-dependent pathway J. Biol. Chem. 284: 6061-6070
  60. Kabuta T, Take K, Kabuta C, Hakuno F, Takahashi S-I. 2008 Differential subcellular localization of insulin receptor substrates dependes on C-terminal regions and importin b. Biochem. Biophys. Res. Commun. 377: 741-746.
  61. Tanigawa K, Suzuki K, Nakamura K, Akama T, Kawashima A, Wu H, Takahashi S-I, Ikuyama S, Ito T, Ishii N. Expression of adipose differentiation-related protein (ADRP) and perilipin in macrophage infected with Mycobacterium leprae. FEMS Microbiology Letters. 289: 72-9
  62. Nagata S, Hakuno F, Takahashi S-I, Nagasawa H. 2008 Identification of Bombyx mori Akt and its phosphorylation by bombyxin stimulation. Comp. Biochem. Physiol. B Biochem. Mol. Biol. 15: 355-360
  63. Fukushima T, Nedachi T, Akizawa H, Akahori M, Hakuno F, Takahashi S-I 2008 Activation of PI 3-kinase in response to cAMP and insulin-like growth factor-I is required for changes in cell cycle regulatory proteins, resulting in cAMP-dependent enhancement of DNA synthesis induced by IGF-I in FRTL-5 cells. Endocrinology 149: 3729-3742.
  64. 豊島由香、高橋伸一郎 2007 IGFシステムによる代謝制御 ホルモンと臨床 55: 307-315
  65. 福嶋俊明、伯野史彦、高橋伸一郎IGFが特定の生理活性を発現する分子メカニズム　-IGF細胞内シグナル伝達系の特徴とその生理的意義-　ホルモンと臨床 55: 259-306
  66. Hakuno F, Kurihara S, Watson RT, Pessin JE, Takahashi S-I. 2007 53BP2, interacting with insulin receptor substrates, modulates insulin signaling. J. Biol. Chem. 282: 37747-37758
  67. Toshiaki Tanaka, Shin-Ichiro Takahashi, Noriyuki Katsumata, Yasuhiko Okimura, Susumu Yokoya, Yutaka Takahashi, Katsuhiko Tachibana, Yukihiro Hasegawa 2007 The Future of GH and IGF Research: Summary of The Third International Congress of the GRS and the IGF Society November 11-15, 2006, Kobe, Japan Ped Endocrinol Rev 4: 362-365
  68. Nenoi M, Daino K, Ichimura S, Takahashi S-I, Akuta T 2006 Low-dose radiation response of the p21WAF1/CIP1 gene promoter transduced by adeno-associated virus vector. Experimental and Molecular Medicine 38: 553-564.
  69. Cho Y, Ariga M, Uchijima Y, Kimura K, Rho J-Y, Furuhata Y, Hakuno F, Yamanouchi K, Nishihara M, Takahashi S-I. 2006 The novel roles of liver for compensation of insulin resistance in human growth hormone transgenic rats. Endocrinology 147:5374−5384.　
  70. 吉倉廣監修、遺伝子組換え実験安全対策研究会編著 2006 よくわかる！研究者のためのカルタヘナ法解説：遺伝子組換え実験の前に知るべき基本ルール　ぎょうせい
  71. 高橋伸一郎、片岡宏誌、神尾好是編著 2006 農芸化学に学ぶ：生活に生きるバイオサイエンス・バイオテクノロジー　エディプロ
  72. 竹中麻子、高橋伸一郎 2006 タンパク質摂取と信号伝達 「分子栄養学」 pp. 91-111（金本龍平編）化学同人
  73. 大坪憲弘、高橋伸一郎、根井充、宮本大、石田大喜 2005 カルタヘナ法の下での遺伝子組換え植物の取扱いについて　Foods and Food Ingredients Journal of Japan 210: 615-624
  74. Anai M, Shojima N, Katagiri H, Ogihara T, Sakoda H, Onishi Y, Ono H, Fujishiro M, Fukushima Y, Horike N, Viana A, Kikuchi M, Noguchi N, Takahashi S-I, Takata K, Oka Y, Uchijima Y, Kurihara H, Asano T. 2005 A novel protein kinase B (PKB)/AKT-binding protein enhances PKB kinase activity and regulates DNA synthesis. J Biol Chem. 280: 18525-18535
  75. Kawashima Y, Kanzaki S, Yang F, Kinoshita Tm Hanaki K, Nagaishi J, Ohtsuka Y, Hisatome I, Ninomiya H, Nanba E, Fukushima T, Takahashi S-I. 2005 Mutation at the cleavage site of IGF receptor in short stature children born with intrauterine growth retardation. J. Clin. Endo. Metab. 90: 4679-4687
  76. Tominaga S, YamaguchiT, Takahashi S-I, Hirose F, Osumi 2005 Negative regulation of adipogenesis from human mesenchymal stem cells by Jun N-terminal kinase. Biochem. Biophys, Res. Commun. 326: 499-504
  77. Iwatsuki K, Okamoto S, Kaneko T, Tanaka K, Kazama R, Nakayama Y, Ito Y, Satake M, Takahashi S-I, Miyajima A, Watanabe T, Hara T 2005 Runx1 promotes angiogenesis by downregulation of insulin-like growth factor-binding protein-3. Oncogene 24; 1129-1137
  78. 高橋伸一郎、石田大喜 2004 教育目的組換えDNA実験を始める前に　遺伝別冊18: 160-170
  79. 高橋伸一郎、石田大喜、宮本大、大坪憲弘、上田順市、根井充　2004 文部科学省における組換えDNA実験指針の法制化　蛋白質核酸酵素 49: 567-572
  80. Kabuta T, Hakuno F, Asano T, Takahashi S-I 2004 IGF/Insulin Receptor Substrate (IRS)-3 in the nucleus functions as a transcriptional co-regulator GH-IGF Res. 14: 124-125.
  81. Toyoshima Y, Ohne Y, Takahashi S-I, Noguchi T, Kato H 2004 Up-regulation of insulin signaling in skeletal muscle of rats by protein malnutrition: Tissue-specific mechanisms through alteration of the status of insulin receptors substrates. J. Mol. Endocrinology. 32: 519-531
  82. Zhang X, Kamaraju S, Hakuno F, Kabuta T, Takahashi S-I, Yee D 2004 Motility response to insulin-like growth factor-I (IGF-I) in MCF-7 cells is associated with IRS-2 activation and integrin expression. Breast Cancer Research and Treatment. 83: 161-170.
  83. 高橋伸一郎、鈴木尚子、伯野史彦 2003 成長ホルモンとインスリンのクロストーク　エクセプタ・メディカ「成長発達」10 (4): 1-7
  84. Okubo Y, Siddle K, Firth H, O’Rahilly S, Wilson LC, Willatt L, Fukushima T, Takahashi S-I, Saukkonen T, Stanhope R, Dunger DB 2003 Cell proliferation activities on skin fibroblasts from a short child with absence of one copy of the type 1 insulin-like growth factor receptor (IGF1R) gene and a tall child with three copies of the IGF1R gene. J. Clin. Endo. Metab. 88: 5981-5988.
  85. Tabei I, Hashimoto H, Ishiwata I, Tokeda Y, Tachibana T, Akahori M, Kyouda S, Kubo H, Yanaga K, Yamazaki Y, Takahashi S-I, Sato K, Ishikawa H 2003 New approach for the establishment of an hepatocyte cell line derived from rat early embryonic stem cells. Human Cell 16: 39-46
  86. Gunton JE, Delhanty PJD, Takahashi S-I, Baxter RC 2003 Metformin rapidly increases insulin receptor activation in human liver and signals preferentially through insulin-receptor substrate-2. J. Clin. Endo. Metab. 88; 1323-1332.
  87. 高橋伸一郎 2002 インスリン様成長因子結合タンパク質の構造と機能 内分泌・糖尿病科 15 (Supple. 1): 110-122
  88. 高橋伸一郎、根建拓、福嶋俊明、大城紀子、梅崎浩太、伊藤芳明、伯野史彦、Judson J Van Wyk、Marco Conti 2002 甲状腺細胞の増殖とcAMP特異的ホスホジエステラーゼ　ホルモンと臨床 50: 183-191
  89. Suzuki N, Hakuno F, Takahashi S-I 2002 Novel mechanisms of insulin resistance in chronically GH-treated 3T3-L1 adipocytes. GH-IGF Res. 12: 280.
  90. Ikawa A, Ishii Y, Suzuki K, Yasoshima A, Suzuki N, Nakayama H, Takahashi S-I, Doi K 2002 Aged-related changes in the dorsal skin histology in mini and Wistar rats. Histol. Histopathol 17: 419-426.
  91. Kabuta T, Hakuno F, Takahashi S-I Insulin receptor substrate-3 functions as transcriptional activator in the nucleus J. Biol. Chem. In press.
  92. 高橋伸一郎 2001 IGFの生理活性の増強と抑制、そして基礎研究から臨床応用へ PRISM 8: 5-6
  93. 高橋伸一郎 2001成長・発達に必須なホルモンIGFの働きとその調節―IGFsの機能から見た生体分子の多様性―IGFsと類似したホルモンの機能の比較、IGFsの活性発現に重要なシグナル分子の機能の比較 PRISM 7: 5-6
  94. 高橋伸一郎 2001成長・発達に必須なホルモンIGFの働きとその調節―IGFの生理活性の調節機構 PRISM 6: 5-6
  95. 高橋伸一郎 2001成長・発達に必須なホルモンIGFの働きとその調節―IGFレセプターと細胞内シグナル伝達 PRISM 5: 5-6
  96. 伯野史彦、有賀美也子、馬場千華、栗原重一、株田智弘、高橋伸一郎 IGFシグナルを増強するタンパク質の同定とその機能の解析 Novo-Nordisk Growth Foudation Reports （印刷中）
  97. 高橋伸一郎 2001成長・発達に必須なホルモンIGFの働きとその調節 −標的細胞近傍でのIGFBPsの生理機能、そしてIGFBPsとIGFBP-rPsのIGFを介さない新しい生理活性 PRISM 4: 5-6
  98. 高橋伸一郎 2001成長・発達に必須なホルモンIGFの働きとその調節 −IGFBPsの性質と産生制御 PRISM 3: 5-6
  99. 高橋伸一郎 2001 成長・発達に必須なホルモンIGFの働きとその調節 −IGFの産生制御- PRISM 2: 5-6
  100. 高橋伸一郎 2001 成長・発達に必須なホルモンIGFの働きとその調節 −はじめに、IGFの発見の経緯・特徴・生理活性- PRISM 1: 5-6
  101. Takahashi S-I, Nedachi T, Fukushima T, Umesaki K, Ito Y, Hakuno F, Van Wyk JJ, Conti M 2001 Long-term hormonal regulation of cAMP-specific phosphodiesterases in cultured FRTL-5 thyroid cells. Biophs. Biochem. Acta. 1540: 68-81.
  102. 根建拓、伯野史彦、高橋伸一郎　2000　エンドクライン型IGFの生理的意義　内分泌・糖尿病科 11: 378-387
  103. 肥塚直美、高橋伸一郎　2000　IGF研究の進歩と展開-ブライトンからのメッセージ　ホルモンと臨床 48: 469-473
  104. 高橋伸一郎　2000　巨大な細胞社会を統御する仕組み「地球を救う50の提案」pp. 94-97. 世界文化社
  105. Kurihara S, Hakuno F, Takahashi S-I 2000 Insulin-like growth factor-I-dependent signal transdcution pathways leading to the induction of cell growth and differentiation of human neuroblastoma cell line, SH-SY5Y; The roles of MAP kinase pathway and PI 3-kianse pathway. Endocrine J. 47: 739-751.
  106. Takenaka A, Oki N, Takahashi S-I, Noguchi T 2000 Dietary restriction of single essential amino acids reduces plasma insulin-like growth factor-I (IGF-I) but does not affect plasma IGF binding protein-1 in rats. J Nutr. 130: 2910-2914.
  107. Nedachi T, Akahori M, Ariga M, Sakamoto H, Umesaki K, Hakuno F, Takahashi S-I 2000 Tyrosine kinase and phosphatidylinositol 3-kinase activities are required for cAMP-dependent potentiation of DNA synthesis induced by insulin-like growth factor-I in FRTL-5 cells. Endocrinology 45: 151-163.
  108. Ariga M, Nedachi T, Akahori M, Sakamoto H, Ito Y, Hakuno F, Takahashi S-I 2000 Signaling pathways of insulin-like growth factor-I that are augmented by cAMP in FRTL-5 cells. Biochem. J. 348: 409-416
  109. Oki N, Takahashi S-I, Hidaka H, Conti M 2000 Short-time feedback regulation of cAMP in FRTL-5 thyroid cells: Role of PDE4D3 phosphodiesterase activation. J. Biol. Chem. 275: 10831-10837
  110. Takenaka A, Komori K, Morishita T, Takahashi S-I, Hidaka T, Noguchi T 2000 Regulation of rat insulin-like growth factor-binding protein-1 gene transcription by amino acid. J. Endocrinol. 164: R11-R16.
  111. 伯野史彦、高橋伸一郎 1999 インスリン様成長因子遺伝子を過剰発現あるいは欠損させたらどうなるか-トランスジェニックマウスおよびノックアウトマウスを用いたIGFsとそのレセプターの機能の解析-　ホルモンと臨床 47: 491-505
  112. Hakuno F, Kurihara S, Kabuta T, Kondo H, Takahashi S-I 1999 Identification of proteins that interact with insulin receptor substrates. Growth Hormone and IGF Research 9: 359
  113. Nedachi T, Akizawa H, Akahori M, Ariga M, Sakamoto H, Umesaki K, Hakuno F, Takahashi S-I 1999 Tyrosine kinase and phosphatidylinositol 3-kinase activities are required for cAMP-dependent potentiation of DNA synthesis induced by insulin-like growth factor-I in FRTL-5 cells. Growth Hormone and IGF Research 9: 360
  114. Ariga M, Akahori M, Nedachi T, Sakamoto H, Hakuno F, Takahashi S-I 1999 Signaling pathways of insulin-like growth factor-I that are augemented by cAMP pretreatment in FRTL-5 cells. Growth Hormone and IGF Research 9: 358
  115. Takahashi S-I 1999 Augementation of intracellular signals of insulin-like growth factor-I by tropic hormones. Growth Hormone and IGF Research 9: 322
  116. Miyatake N, Shikata K, Wada J, Sugimoto H, Takahashi S-I, Makino H 1999 Differential distribution of insulin-like growth factor-1 (IGF-1) and insulin-like growth factor binding proteins (IGFBPs) in experimental diabetic rat kidney. Nephron 81: 317-323
  117. 高橋伸一郎、伯野史彦 1998 24章　増殖因子．「細胞機能と代謝マップII．?部細胞間コミュニケーション」．pp. 186-199. 東京化学同人．
  118. 高橋伸一郎、伯野史彦 1998 インスリン様成長因子をめぐる話題．BIO Clinica 13: 963-969
  119. 高橋伸一郎、伯野史彦 1998 インスリン様成長因子の細胞内シグナル伝達．ホルモンと臨床 46: 89-104
  120. 高橋伸一郎 1998 インスリン様成長因子の生理活性の調節．日本農芸化学会誌 72: 161-166
  121. 高橋伸一郎 1998 インスリン様成長因子とは何か．日本農芸化学会誌 72: 159-160
  122. Takano K, Hizuka N, Takahashi S-I 1998 "Molecular mechanisms to regulate insulin-like growth factors' activities", Elsevier, Amsterdam, New York, Tokyo,
  123. Koide T, Ono Y, Ito Y, Akahori M, Nedachi T, Takenaka A, Hakuno F, Takahashi S-I, Noguchi T 1998 Insulin-like growth factor-I potentiates protein synthesis induced by thyrotropin in FRTL-5 cells. Endocrine J. 45: 151-163
  124. Ito Y, Takahashi S-I, Takenaka A, Hidaka T, Noguchi T 1997 Starvation enhanced insulin-dependent tyrosine phosphorylation of the 195 kDa protein in rat intact liver. Biosci. Biotech. Biochem. 61: 2122-2124
  125. Ito Y, Ariga M, Takahashi S-I, Takenaka A, Hidaka T, Noguchi T 1997 Phosphorylation of insulin receptor, insulin receptor substrate-1 (IRS-1) and association of phosphatidylinositol 3-kinase subunit with IRS-1 after a meal in vivo in rat liver. J. Endocrinol. 154: 267-273
  126. Ito Y, Ariga M, Uchijima Y, Takenaka A, Hakuno F, Takahashi S-I, Ariga T, Noguchi T 1997 Interaction between cAMP-dependent and insulin-dependent signal pathways in tyrosine phosphorylation in primary cultures of rat hepatocytes. Biochem. J. 324: 379-388.
  127. 高橋伸一郎、竹中麻子、野口忠 1996 動物の成長をつかさどるホルモン、インスリン様成長因子-I．蛋白質核酸酵素 41: 267-280
  128. Takahashi S-I, Takenaka A, Noguchi T 1994 Relationship between nutrient intake and insulin-like growth factor I (IGF-I) Clin. Ped. Endocrinology 3:111-114.
  129. Van Wyk JJ, Takahashi S-I, Conti M, Dai Z, D'Ercole AJ 1993 Development of a model system to investigate autocrine modalities of growth factor actions. In: Growth Factors in Perinatal Development, Raven Press, New York, pp.71-90
  130. Dai Z, Takahashi S-I, Van Wyk JJ, D'Ercole AJ 1992 Creation of an autocrine model of insulin-like growth factor-I action in transformed FRTL-5 cells. Endocrinology 130: 3175-3183
  131. Takahashi S-I, Conti M, Prokop C, Van Wyk JJ, Earp HS 1991 TSH and IGF-I regulation of tyrosine phosphorylation in FRTL-5 cells. J. Biol. Chem. 266: 7834-7841
  132. Van Wyk JJ, Conti M, Del Monte P, Takahashi S-I 1990 The role of somatomedins in the growth and function of endocrine tissues. In: Developmental Endocrinology, Raven Press, New York, pp. 127-141
  133. Takahashi S-I, Conti M, Van Wyk JJ 1990 Thyrotropin potentiation of insulin-like growth factor-I dependent deoxyribonucleic acid synthesis in FRTL-5 cells. Endocrinology 126: 736-745